Home Ripple Ripple Therapeutics Research on Polymer-Free Drug Delivery Published in Nature Communications

Ripple Therapeutics Research on Polymer-Free Drug Delivery Published in Nature Communications

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TORONTO, ON / ACCESSWIRE / June 1, 2021 / Ripple Therapeutics Company (“Ripple”), a medical stage, ophthalmology-focused developer of novel prescribed drugs, introduced right this moment that the article Polymer-Free Corticosteroid Dimer Implants for Managed and Sustained Drug Supply was not too long ago revealed in Nature Communications.

The article describes Ripple’s Epidel™ know-how platform which is based on a discovery that medicine might be engineered into drug supply implants with out using polymers or excipients. The proprietary prodrugs are new chemical entities (NCEs) which have distinctive properties that permit them to be processed into standalone drug supply implants (e.g. implantable cylinders, micro/nanoparticles, and so forth.) or as coatings for medical gadgets and not using a polymeric service. Ripple Therapeutics’ implants and coatings are made up solely from the prodrug so when the drug is gone the implant is gone. The implants and coatings bear floor erosion reaching tightly managed and reproducible launch kinetics. Drug launch profiles are extremely engineerable (e.g. completely different varieties, shapes, and sizes) to tailor drug dose and length for the precise indication of curiosity. The pliability in molecular design leads to drug doses which are inside the therapeutic window for a specified length, delivering the correct quantity of drug for the correct quantity of time. This has the potential to enhance affected person security and medical outcomes.

“Floor erosion-based drug launch allows probably the most controllable approach to exactly design pharmacokinetics and pharmacodynamics for a goal indication,” commented Dr. Wendy Naimark, Chief Expertise Officer, Ripple Therapeutics. “We purposely design for simplicity to fulfill each security and manufacturing targets. The much less materials the higher from a physiological perspective and manufacturing simplicity is vital for making certain course of management and finally a decrease price of products.”

Ripple not too long ago introduced that the primary sufferers have been enrolled in RIPPLE-1, a Part II medical trial evaluating IBE-814 IVT, a proprietary intravitreal dexamethasone implant concentrating on DME (diabetic macular edema) and RVO (retinal vein occlusion) sufferers. The trial seeks to supply a much-needed remedy choice: a safer steroid implant with an prolonged medical profit.

Ripple is creating a full product pipeline together with sustained launch therapeutics for glaucoma, put up cataract surgical procedure and AMD. Ripple’s glaucoma product (RTC-1119) is an intracameral prostaglandin implant for major open-angle glaucoma. The goal product profile for RTC-1119 is to supply managed, predictable drug launch for 6-12 months and to permit retreatments as required. The product is presently in preclinical growth and the corporate is on track to submit a pre-IND within the second quarter of 2022.

To learn the article go to: https://www.nature.com/articles/s41467-021-23232-7

About Ripple Therapeutics

Ripple Therapeutics Company is a medical stage, privately held firm that’s centered on ophthalmic therapeutics with controllable, sustainable drug supply. The core characteristic of Ripple’s Epidel™ know-how is the flexibility to engineer sustained-release prescribed drugs with zero-order launch kinetics with out using polymers or excipients. Ripple has a full product pipeline in growth. www.rippletherapeutics.com

Media Contact

Julie Fotheringham, V.P. Advertising and marketing, Folks & Tradition

M: 416-951-7988 E: jfotheringham@rippletherapeutics.com

SOURCE: Ripple Therapeutics Company


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